This paper highlights a work under development on a regional competitiveness project. We
report on a multi-lateral, multi-scale perspective for building cooperative relationships that
enhance competitiveness Regionally. The approach mimics a System of Systems methodology
whereby entity relationships are captured and defined along several dimensions involving
multiple constituents and multiple domain concerns. We build a serious game that is a
distributed business simulator to approach the prototyping of this crossroads between supply
chain management, geographical economics and information systems.