For achieving faster communication most of confidential data is circulated through networks as electronic data. Cryptographic ciphers have an important role for providing security to these confidential data against unauthorized attacks. Though security is an important factor, there are various factors that can affect the performance and selection of cryptographic algorithms during the practical implementation of these cryptographic ciphers for various applications. This paper provides analysis and comparison of some symmetric key cryptographic ciphers (RC4, AES, Blowfish, RC2, DES, Skipjack, and Triple DES) on the basis of encryption time with the variation of various file features like different data types, data size, data density and key sizes.