Total column water vapor is an important factor for the weather and climate. This study apply deep learning based multiple regression to map the TCWV with elements that can improve spatiotemporal prediction. In this study, we predict the TCWV with the use of ERA5 that is the fifth generation ECMWF atmospheric reanalysis of the global climate. We use an appropriate deep learning based multiple regression algorithm using Keras library to improve nonlinear prediction between Total Column water vapor and predictors as Mean sea level pressure, Surface pressure, Sea surface temperature, 100 metre U wind component, 100 metre V wind component, 10 metre U wind component, 10 metre V wind component, 2 metre dew point temperature, 2metre temperature. The results obtained permit to build a predictor which modelling TCWV with a mean abs error (MAE) equal to 3.60 kg/m2 and a coefficient of determination R2 equal to 0.90.