Physical treatments such as therapeutic ultrasound and Laser are cited as important aides in wound management. This work expected to assess the role of ultrasound and laser on excisional wound healing progression in incited diabetic mice. Forty Swiss albino mice were divided into 2 groups; group I (diabetic free, 10mice) was used as a control group, while the other; group II(30 mice) was diabetic induced. Circular wounds were created on the dorsal fur of the animals. The wounds of laser treated group (N=10) were exposed to laser irradiation (830nm, 60mW), 5 minutes daily, 5 days/week until the wounds healed completely. The wounds of ultrasound treated group (N=10) were exposed to pulsed ultrasound (0.5 W/cm2 , 1MHz) 5 minutes daily until the wounds healed completely. The untreated group (N=10) wound was left without treatment. The wounds for control group did not receive any type of treatment. The healing was noticed and assessed during the treatment period. Histological anal